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Genetic characteristics and pathogenesis of clade 2.3.4.4b H5N1 high pathogenicity avian influenza virus isolated from poultry in South Korea, 2022-2023.

Virus research - 1 Mar 2025

Cha Ra Mi, Park Min-Ji, Baek Yoon-Gi, Lee Yu-Na, Jang Yunyueng, Kang Yong-Myung, Heo Gyeong-Beom, An Se-Hee, Lee Kwang-Nyeong, Kim Jae-Kyeom, Kim Hye-Ryoung, Lee Youn-Jeong, Lee Eun-Kyoung

Abstract excerpt

During the 2022-2023 winter season in South Korea, a novel clade 2.3.4.4b H5N1 HPAIV was first detected in wild birds, which then subsequently caused multiple outbreaks in poultry farms and wild birds. This study aimed to investigate the genetic characteristics of H5N1 HPAIVs isolated during the 2022-2023, along with their pathogenicity and transmissibility in chickens and ducks. The clade 2.3.4.4b H5N1 HPAIV...

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PMID: 39894372
DOI: 10.1016/j.virusres.2025.199541
PMCID: PMC11850744

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