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A Sequence-Based Update on Amino Acid Substitutions in Influenza Polymerase Acidic Protein in Europe That Alter Baloxavir Susceptibility From 2009 to 2025.

Influenza and other respiratory viruses - 1 Jul 2026

Martín-Toribio Alejandro, Inchausti-Moya Inés, Toquero-Asensio Marina, García-Díaz Sonia, Sanchez-Martinez Javier, Rodriguez-Crespo Carla, Galindo-Carretero Silvia, Iglesia-Aparicio Raquel, Lopez-Gonzalo Celia, Antón-Contreras Ana, Rojo-Rello Silvia, Dominguez-Gil Marta, Hernández Marta, Eiros Jose M, Nistal-Villan Estanislao, Sanz-Muñoz Iván

Abstract excerpt

BACKGROUND: Influenza causes 650,000 deaths, 3-5 million hospitalizations, and 1 billion cases worldwide each year. There is a limited repertoire of antivirals available to tackle this burden, highlighting the risk of developing resistance to current drugs. An effort to develop new influenza antivirals has been made, leading to the approval of baloxavir. Some mutations leading to reduced susceptibility to...

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Drug Resistance, Viral
Europe
Influenza, Human
Morpholines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA-Dependent RNA Polymerase

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Identifiers

PMID: 42359554
DOI: 10.1111/irv.70288
PMCID: PMC13306115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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