Article

Dissecting human skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses

2020-12-22

Abstract excerpt

Human skeletal stem cells (SSCs) have been discovered in fetal and adult bones. However, the spatiotemporal ontogeny of human SSCs during embryogenesis has been elusive. Here we map the transcriptional landscape of human embryonic skeletogenesis at single-cell resolution to address this fundamental question. We found remarkable heterogeneity within human limb bud mesenchyme and epithelium, as well as the earliest...

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Literature Corpus work: cd34dfa0-9b88-5ed4-b3c0-e43c0ca88496
DOI: 10.1101/2020.12.22.423948

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