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Article

A computationally designed antigen eliciting broad humoral responses against SARS-CoV-2 and related sarbecoviruses

25 Sept 2023

Abstract excerpt

The threat of spillovers of coronaviruses associated with the severe acute respiratory syndrome (SARS) from animals to humans necessitates vaccines that offer broader protection from sarbecoviruses. By leveraging a viral-genome-informed computational method for selecting immune-optimized and structurally engineered antigens, here we show that a single antigen based on the receptor binding domain of the spike...

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PMID: 37749309
DOI: 10.1038/s41551-023-01094-2

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