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Article

Effect of N-glycosylation on constitutive signal transduction by mutated cytokine receptor-like factor 2.

Biochimica et biophysica acta. General subjects - 1 Nov 2023

Yamamoto Rio, Segawa Ryosuke, Liu Jianwei, Isaji Tomoya, Gu Jianguo, Hiratsuka Masahiro, Hirasawa Noriyasu

Abstract excerpt

BACKGROUND: Cytokine receptor-like factor 2 (CRLF2) is a subunit of the receptor for thymic stromal lymphopoietin (TSLP). A somatic mutation (insEIM) in the transmembrane domains of CRLF2 has been identified in acute lymphocytic leukemia (ALL), and Glu-Ile-Met (EIM) CRLF2 induces constitutive activation of signals. However, the signaling mechanism remains unclear. METHODS: HEK293 cells were transfected with...

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Share to TSLP gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 37748663
DOI: 10.1016/j.bbagen.2023.130465

Genes

CRLF2
MGAT1
TSLP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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