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Article

Exploiting the weak link: Ataxia-Telangiectasia Mutated dysfunction in oesophagogastric tumours.

Critical reviews in oncology/hematology - 1 Oct 2026

Trybala Zuzanna, Costella Giulia, Bednarova Kristina, Arcimowicz Łukasz, Aigner Achim, Lordick Florian, Obermannová Radka Lordick, Müller Petr

Abstract excerpt

ATM (ataxia-telangiectasia mutated) is a central regulator of the DNA damage response, coordinating double-strand break repair, checkpoint control, and cell fate decisions. Its disruption drives genomic instability and has been implicated across multiple tumour types. In oesophagogastric cancers, ATM alterations occur in a clinically relevant subset of cases, encompassing both somatic and germline events, and are...

Read the complete abstract on PubMed

Topics

Humans
Ataxia Telangiectasia Mutated Proteins
Esophageal Neoplasms
Stomach Neoplasms
Mutation
Animals

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 42532225
DOI: 10.1016/j.critrevonc.2026.105503

Genes

ATM
ATR
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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