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Article

A PAX6-regulated receptor tyrosine kinase pairs with a pseudokinase to activate immune defense upon oomycete recognition in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 26 Sept 2023

Drury Florence, Grover Manish, Hintze Mark, Saunders Jonathan, Fasseas Michael K, Constantinou Charis, Barkoulas Michalis

Abstract excerpt

Oomycetes were recently discovered as natural pathogens of Caenorhabditis elegans, and pathogen recognition alone was shown to be sufficient to activate a protective transcriptional program characterized by the expression of multiple chitinase-like (chil) genes. However, the molecular mechanisms underlying oomycete recognition in animals remain fully unknown. We performed here a forward genetic screen to uncover...

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PMID: 37725647
DOI: 10.1073/pnas.2300587120
PMCID: PMC10523662

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