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Article

The immunogenicity of human-origin therapeutic antibodies are associated with V gene usage.

Frontiers in immunology - 1 Jan 2023

Hu Zicheng, Cohen Sivan, Swanson Steven J

Abstract excerpt

Therapeutic antibodies can elicit unwanted immune responses in a subset of patients, which leads to the production of anti-drug antibodies (ADA). Some of these ADAs have been reported to effect the pharmacokinetics, efficacy and/or safety of the therapeutic antibodies. The sequence diversity of antibodies are generated by VDJ recombination and mutagenesis. While the antibody generation process can create a large...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37720227
DOI: 10.3389/fimmu.2023.1237754
PMCID: PMC10502710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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