Anti-InlA single-domain antibodies that inhibit the cell invasion of Listeria monocytogenes

Abstract excerpt

Listeriosis, caused by infection with Listeria monocytogenes , is a severe disease with a high mortality rate. The L. monocytogenes virulence factor, internalin family protein InlA, which binds to the host receptor E-cadherin, is necessary to invade host cells. Here, we isolated two single-domain antibodies (V H Hs) that bind to InlA with picomolar affinities from an alpaca immune library using the phage display...

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