Article
Aberrant splicing of mutant huntingtin in Huntington's disease knock-in pigs.
Neurobiology of disease - 15 Oct 2023
Tong Huichun, Yang Tianqi, Liu Li, Li Caijuan, Sun Yize, Jia Qingqing, Qin Yiyang, Chen Laiqiang, Zhao Xianxian, Zhou Gongke, Yan Sen, Li Xiao-Jiang, Li Shihua
Abstract excerpt
Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disease caused by a CAG repeat expansion in exon1 of the huntingtin gene (HTT). This expansion leads to the production of N-terminal mutant huntingtin protein (mHtt) that contains an expanded polyglutamine tract, which is toxic to neurons and causes neurodegeneration. While the production of N-terminal mHtt can be mediated by...
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