Article
Species-dependent neuropathology in transgenic SOD1 pigs.
Cell research - 1 Apr 2014
Yang Huaqiang, Wang Guohao, Sun Haitao, Shu Runzhe, Liu Tao, Wang Chuan-En, Liu Zhaoming, Zhao Yu, Zhao Bentian, Ouyang Zhen, Yang Dongshan, Huang Jiao, Zhou Yueling, Li Shihua, Jiang Xiaodan, Xiao Zhicheng, Li Xiao-Jiang, Lai Liangxue
Abstract excerpt
Mutations in the human copper/zinc superoxide dismutase 1 (hSOD1) gene cause familial amyotrophic lateral sclerosis (ALS). It remains unknown whether large animal models of ALS mimic more pathological events seen in ALS patients via novel mechanisms. Here, we report the generation of transgenic pigs expressing mutant G93A hSOD1 and showing hind limb motor defects, which are germline transmissible, and motor...
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