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Structural landscape of the respiratory syncytial virus nucleocapsids

15 Sept 2023

Abstract excerpt

Human Respiratory Syncytial Virus (HRSV) is a prevalent cause of severe respiratory infections in children and the elderly. The helical HRSV nucleocapsid is a template for the viral RNA synthesis and a scaffold for the virion assembly. This cryo-electron microscopy analysis reveals the non-canonical arrangement of the HRSV nucleocapsid helix, composed of 16 nucleoproteins per asymmetric unit, and the resulting...

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PMID: 37714861
DOI: 10.1038/s41467-023-41439-8

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