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Decreased AKAP4/PKA signaling pathway in high DFI sperm affects sperm capacitation

15 Aug 2023

Abstract excerpt

The sperm DNA fragmentation index (DFI) is a metric used to assess DNA fragmentation within sperm. During in vitro fertilization-embryo transfer (IVF-ET), high sperm DFI can lead to a low fertilization rate, poor embryo development, early miscarriage, etc. A kinase anchoring protein (AKAP) is a scaffold protein that can bind protein kinase A (PKA) to subcellular sites of specific substrates and protects the...

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PMID: 37695244
DOI: 10.4103/aja202329

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