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A Kinase Anchor Protein 4 Is Vulnerable to Oxidative Adduction in Male Germ Cells

20 Dec 2019

Abstract excerpt

Oxidative stress is a leading causative agent in the defective sperm function associated with male infertility. Such stress commonly manifests via the accumulation of pathological levels of the electrophilic aldehyde, 4-hydroxynonenal (4HNE), generated as a result of lipid peroxidation. This highly reactive lipid aldehyde elicits a spectrum of cytotoxic lesions owing to its propensity to form stable adducts with...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 31921838
DOI: 10.3389/fcell.2019.00319

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