Article

Redox Dyshomeostasis Links Renal and Neuronal Dysfunction in <i>Drosophila</i> Models of Gaucher and Parkinson’s Disease

2025-08-09

Abstract excerpt

Gaucher disease (GD), the most common lysosomal storage disorder, is caused by bi-allelic mutations in the GBA1 gene. Variants in GBA1 also represent the most frequent genetic risk factor for Parkinson’s disease (PD). Although GD and PD are clinically distinct disorders, they share key pathological features, including lysosomal dysfunction, mitochondrial stress, and redox imbalance. While PD has traditionally be...

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Literature Corpus work: 9d5d8364-90f9-572e-9beb-58a3643c6b5a
DOI: 10.1101/2025.08.06.668868

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