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Article

An abundant quiescent stem cell population in Drosophila Malpighian tubules protects principal cells from kidney stones.

eLife - 16 Mar 2020

Wang Chenhui, Spradling Allan C

Abstract excerpt

Adult Drosophila Malpighian tubules have low rates of cell turnover but are vulnerable to damage caused by stones, like their mammalian counterparts, kidneys. We show that Drosophilarenal stem cells (RSCs) in the ureter and lower tubules comprise a unique, unipotent regenerative compartment. RSCs respond only to loss of nearby principal cells (PCs), cells critical for maintaining ionic balance. Large polyploid...

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Identifiers

PMID: 32175841
DOI: 10.7554/eLife.54096
PMCID: PMC7093152

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