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Article

Pediatric Features of Genetic Predisposition to Polycystic Ovary Syndrome.

The Journal of clinical endocrinology and metabolism - 18 Jan 2024

Zhu Jia, Eliasen Anders U, Aris Izzuddin M, Stinson Sara E, Holm Jens-Christian, Hansen Torben, Hivert Marie-France, Bønnelykke Klaus, Salem Rany M, Hirschhorn Joel N, Chan Yee-Ming

Abstract excerpt

CONTEXT: Polycystic ovary syndrome (PCOS) has historically been conceptualized as a disorder of the reproductive system in women. However, offspring of women with PCOS begin to show metabolic features of PCOS in childhood, suggestive of childhood manifestations. OBJECTIVE: To identify childhood manifestations of genetic risk for PCOS. METHODS: We calculated a PCOS polygenic risk score (PRS) for 12 350 girls and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37690116
DOI: 10.1210/clinem/dgad533
PMCID: PMC10795915

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