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Human early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infection

17 Nov 2022

Abstract excerpt

Direct in vivo investigation of human placenta trophoblast's susceptibility to SARS-CoV-2 is challenging. Here we report that human trophoblast stem cells (hTSCs) and their derivatives are susceptible to SARS-CoV-2 infection, which reveals heterogeneity in hTSC cultures. Early syncytiotrophoblasts (eSTBs) generated from hTSCs have enriched transcriptomic features of peri-implantation trophoblasts, express high...

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PMID: 36495872
DOI: 10.1016/j.xcrm.2022.100849

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