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Lineage classification and antitubercular drug resistance surveillance of Mycobacterium tuberculosis by whole-genome sequencing in Southern India.

Microbiology spectrum - 17 Oct 2023

Rao Mahadev, Wollenberg Kurt, Harris Michael, Kulavalli Shrivathsa, Thomas Levin, Chawla Kiran, Shenoy Vishnu Prasad, Varma Muralidhar, Saravu Kavitha, Hande H Manjunatha, Shanthigrama Vasudeva Chidananda Sanju, Jeffrey Brendan, Gabrielian Andrei, Rosenthal Alex

Abstract excerpt

IMPORTANCE: Studies mapping genetic heterogeneity of clinical isolates of M. tuberculosis for determining their strain lineage and drug resistance by whole-genome sequencing are limited in high tuberculosis burden settings. We carried out whole-genome sequencing of 242 M. tuberculosis isolates from drug-sensitive and drug-resistant tuberculosis patients, identified and collected as part of the TB Portals Program,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37671895
DOI: 10.1128/spectrum.04531-22
PMCID: PMC10580826

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