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Mycobacterium tuberculosis Lineages Associated with Mutations and Drug Resistance in Isolates from India.

Microbiology spectrum - 29 Jun 2022

Shanmugam Siva Kumar, Kumar Narender, Sembulingam Tamilzhalagan, Ramalingam Suresh Babu, Selvaraj Ashok, Rajendhiran Udhayakumar, Solaiyappan Sudha, Tripathy Srikanth P, Natrajan Mohan, Chandrasekaran Padmapriyadarsini, Swaminathan Soumya, Parkhill Julian, Peacock Sharon J, Ranganathan Uma Devi K

Abstract excerpt

Current knowledge on resistance-conferring determinants in Mycobacterium tuberculosis is biased toward globally dominant lineages 2 and 4. In contrast, lineages 1 and 3 are predominant in India. In this study, we performed whole-genome sequencing of 498 MDR M. tuberculosis isolates from India to determine the prevalence of drug resistance mutations and to understand the genomic diversity. A retrospective...

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Identifiers

PMID: 35442078
DOI: 10.1128/spectrum.01594-21
PMCID: PMC9241780

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