Article
Mycobacterium tuberculosis Whole Genome Sequences From Southern India Suggest Novel Resistance Mechanisms and the Need for Region-Specific Diagnostics.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Jun 2017
Manson Abigail L, Abeel Thomas, Galagan James E, Sundaramurthi Jagadish Chandrabose, Salazar Alex, Gehrmann Thies, Shanmugam Siva Kumar, Palaniyandi Kannan, Narayanan Sujatha, Swaminathan Soumya, Earl Ashlee M
Abstract excerpt
BACKGROUND.: India is home to 25% of all tuberculosis cases and the second highest number of multidrug resistant cases worldwide. However, little is known about the genetic diversity and resistance determinants of Indian Mycobacterium tuberculosis, particularly for the primary lineages found in India, lineages 1 and 3. METHODS.: We whole genome sequenced 223 randomly selected M. tuberculosis strains from 196...
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