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Whole genome sequencing of clinical strains of Mycobacterium tuberculosis from Mumbai, India: A potential tool for determining drug-resistance and strain lineage.

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2017

Chatterjee Anirvan, Nilgiriwala Kayzad, Saranath Dhananjaya, Rodrigues Camilla, Mistry Nerges

Abstract excerpt

Amplification of drug resistance in Mycobacterium tuberculosis (M.tb) and its transmission are significant barriers in controlling tuberculosis (TB) globally. Diagnostic inaccuracies and delays impede appropriate drug administration, which exacerbates primary and secondary drug resistance. Increasing affordability of whole genome sequencing (WGS) and exhaustive cataloguing of drug resistance mutations is poised...

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PMID: 29050774
DOI: 10.1016/j.tube.2017.08.002

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