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Neutrophil metalloproteinase driven spleen damage hampers infection control of trypanosomiasis

5 Sept 2023

Abstract excerpt

Abstract Recent blood transcriptomic analysis of rhodesiense sleeping sickness patients has revealed that neutrophil signature genes and activation markers constitute the top indicators of trypanosomiasis-associated inflammation. Here, we show that Trypanosoma brucei infection results in expansion and differentiation of four splenic neutrophil subpopulations, including Mki67+Birc5+Gfi1+Cebpe+...

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PMID: 37669943
DOI: 10.1038/s41467-023-41089-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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