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Heterotopic Ossifications in a Mouse Model of Albright Hereditary Osteodystrophy

29 Jun 2011

Abstract excerpt

Albright hereditary osteodystrophy (AHO) is characterized by short stature, brachydactyly, and often heterotopic ossifications that are typically subcutaneous. Subcutaneous ossifications (SCO) cause considerable morbidity in AHO with no effective treatment. AHO is caused by heterozygous inactivating mutations in those GNAS exons encoding the α-subunit of the stimulatory G protein (Gα(s)). When inherited...

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PMID: 21747923
DOI: 10.1371/journal.pone.0021755

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