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A variant in sperm‐specific glycolytic enzyme enolase 4 (ENO4) causes human male infertility

28 Aug 2023

Abstract excerpt

BACKGROUND: Although defects in sperm morphology and physiology lead to male infertility, in many instances, the exact disruption of molecular pathways in a given patient is often unknown. The glycolytic pathway is an essential process to supply energy in sperm cell motility. Enolase 4 (ENO4) is crucial for the glycolytic process, which provides the energy for sperm cells in motility. ENO4 is located in the sperm...

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PMID: 37640479
DOI: 10.1002/jgm.3583

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