Article
DinB (DNA polymerase IV), ImuBC and RpoS contribute to the generation of ciprofloxacin-resistance mutations in Pseudomonas aeruginosa.
Mutation research - 1 Jan 2000
Fahey Declan, O'Brien James, Pagnon Joanne, Page Simone, Wilson Richard, Slamen Nic, Roddam Louise, Ambrose Mark
Abstract excerpt
We investigated the role(s) of the damage-inducible SOS response dinB and imuBC gene products in the generation of ciprofloxacin-resistance mutations in the important human opportunistic bacterial pathogen, Pseudomonas aeruginosa. We found that the overall numbers of ciprofloxacin resistant (CipR) mutants able to be recovered under conditions of selection were significantly reduced when the bacterial cells...
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