Article
Linked mutations within the pathogenicity locus of Clostridioides difficile increase virulence.
Infectious diseases (London, England) - 1 Dec 2023
Lin Qianyun, Li Zitong, Ke Haoran, Fei Jiaxi, Zhang Ting, Wang Pu, Chen Ye
Abstract excerpt
BACKGROUND: The clinical manifestations of Clostridioides difficile infections range from diarrhoea to pseudomembranous colitis (PMC) and death. We evaluated the association between gene content in C. difficile clinical isolates and disease severity. METHODS: Fifty-three C. difficile isolates were subjected to Sanger sequencing, clinical data were used to analyse the association of gene content with disease...
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