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Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma

16 Mar 2023

Abstract excerpt

Apicomplexan parasites use Ca 2+ -regulated exocytosis to secrete essential virulence factors from specialized organelles called micronemes. Ca 2+ -dependent protein kinases (CDPKs) are required for microneme exocytosis; however, the molecular events that regulate trafficking and fusion of micronemes with the plasma membrane remain unresolved. Here, we combine sub-minute resolution phosphoproteomics and...

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PMID: 37933960
DOI: 10.7554/elife.85654

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