Article
Artificial intelligence for dementia genetics and omics.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Dec 2023
Bettencourt Conceicao, Skene Nathan, Bandres-Ciga Sara, Anderson Emma, Winchester Laura M, Foote Isabelle F, Schwartzentruber Jeremy, Botia Juan A, Nalls Mike, Singleton Andrew, Schilder Brian M, Humphrey Jack, Marzi Sarah J, Toomey Christina E, Kleifat Ahmad Al, Harshfield Eric L, Garfield Victoria, Sandor Cynthia, Keat Samuel, Tamburin Stefano, Frigerio Carlo Sala, Lourida Ilianna, Ranson Janice M, Llewellyn David J
Abstract excerpt
Genetics and omics studies of Alzheimer's disease and other dementia subtypes enhance our understanding of underlying mechanisms and pathways that can be targeted. We identified key remaining challenges: First, can we enhance genetic studies to address missing heritability? Can we identify reproducible omics signatures that differentiate between dementia subtypes? Can high-dimensional omics data identify improved...
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