Article
The polygenic basis of relapse after a first episode of schizophrenia.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Oct 2023
Segura Àlex-González, Prohens Llucia, Gassó Patricia, Rodríguez Natalia, Garcia-Rizo Clemente, Moreno-Izco Lucía, Andreu-Bernabeu Álvaro, Zorrilla Iñaki, Mane Anna, Rodriguez-Jimenez Roberto, Roldán Alexandra, Sarró Salvador, Ibáñez Ángela, Usall Judith, Sáiz Pilar A, Cuesta Manuel J, Parellada Mara, González-Pinto Ana, Berrocoso Ester, Bernardo Miquel, Mas Sergi, Mezquida Gisela, Arbelo Néstor, De Matteis Mario, Galvañ Joaquín, Duque Guerra Alejandra, Arias I Queralt Laia, Perez-Bacigalupe Maria, Gonzalez-Ortega Itxaso, Toll Alba, Casanovas Francesc, Sanchez-Pastor Luis, Valtueña Mercedes, Pomarol-Clotet Edith, García-León Maria Ángeles, Butjosa Ana, Rubio-Abadal Elena, Ribeiro María, López-Ilundain Jose M, Saiz-Ruiz Jeronimo, León-Quismondo Luis, Rivero Olga, Ruiz Pedro, Echevarría Rafael Segarra, García-Portilla M Paz
Abstract excerpt
Little is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia and bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims to explore the potential role of PRS from major mental disorders and cognition on schizophrenia relapse. 114 patients recruited in the 2EPs Project were included...
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