Article
Mitochondrial displacement loop region single nucleotide polymorphisms and mitochondrial DNA copy number associated with risk of ankylosing spondylitis.
International journal of rheumatic diseases - 1 Nov 2023
Zhang Jingjing, Peng Chenxing, Xu Shuo, Zhao Yufei, Zhang Xiaoyun, Zhang Shasha, Guo Zhanjun
Abstract excerpt
AIM: The pathogenesis of ankylosing spondylitis (AS) seems to be associated with genetics, the environment, heredity, and oxidative stress. Single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) region of mitochondrial DNA (mtDNA) and mtDNA copy number were investigated for their correlation with AS patients. METHODS: This study included 83 AS patients and 100 healthy controls from the Second...
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