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The phenuivirus Toscana virus makes an atypical use of vacuolar acidity to enter host cells

14 Aug 2023

Abstract excerpt

Toscana virus is a major cause of arboviral disease in humans in the Mediterranean basin during summer. However, early virus-host cell interactions and entry mechanisms remain poorly characterized. Investigating iPSC-derived human neurons and cell lines, we found that virus binding to the cell surface was specific, and 50% of bound virions were endocytosed within 10 min. Virions entered Rab5a+ early endosomes...

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PMID: 37578957
DOI: 10.1371/journal.ppat.1011562

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