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Article

Cytochrome P450 3A4 activity and genetic variants as predictors of liver failure in patients with obstructive jaundice.

Free radical biology & medicine - 1 Nov 2023

Lebedev Sergey S, Tavobilov Mikhail M, Karpov Alexey A, Abramov Kirill A, Bochkov Pavel O, Shevchenko Roman V, Denisenko Natalia P, Shabunin Alexey V, Sychev Dmitri A

Abstract excerpt

Liver failure in patients with obstructive jaundice is a significant contributor to mortality within this patient cohort. The exact mechanism and triggers of this occurrence are yet to be fully understood. With this in mind, our study aimed to assess the correlation between the urinary 6 β-OHC/C ratio and various biochemical parameters of liver function. Furthermore, we conducted genotyping of CYP3A4*22...

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PMID: 37573895
DOI: 10.1016/j.freeradbiomed.2023.08.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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