Article
Identification of diuretic non-responders with poor long-term clinical outcomes: a 1-year follow-up of 176 non-azotaemic cirrhotic patients with moderate ascites.
Clinical science (London, England : 1979) - 1 Dec 2011
Yang Ying-Ying, Lin Han-Chieh, Lin Ming-Wei, Chu Chi-Jen, Lee Fa-Yauh, Hou Ming-Chih, Lee Shou-Dong, Lee Wei-Ping, Liu Tze-Tze, Jap Tjin-Shing
Abstract excerpt
In cirrhosis, the development of ascites and the response to diuretics are determined by the RAAS (renin-angiotensin-aldosterone system) and renal sodium handling system. We hypothesized that SNPs (single nucleotide polymorphisms) affecting candidate genes in the RAAS and renal sodium handling pathway may influence initial diuretic responsiveness and affect clinical outcome in non-azotaemic cirrhotic patients...
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