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Spike protein mutations and structural insights of pangolin lineage B.1.1.25 with implications for viral pathogenicity and ACE2 binding affinity.

Scientific reports - 12 Aug 2023

Akter Shahina, Oliveira Jonas Ivan Nobre, Barton Carl, Sarkar Murshed Hasan, Shahab Muhammad, Banu Tanjina Akhtar, Goswami Barna, Osman Eshrar, Uzzaman Mohammad Samir, Nafisa Tasnim, Molla Maruf Ahmed, Yeasmin Mahmuda, Farzana Maisha, Habib Ahashan, Shaikh Aftab Ali, Khan Salim

Abstract excerpt

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of COVID -19, is constantly evolving, requiring continuous genomic surveillance. In this study, we used whole-genome sequencing to investigate the genetic epidemiology of SARS-CoV-2 in Bangladesh, with particular emphasis on identifying dominant variants and associated mutations. We used high-throughput next-generation sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37573409
DOI: 10.1038/s41598-023-40005-y
PMCID: PMC10423208

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