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Impact of the Double Mutants on Spike Protein of SARS-CoV-2 B.1.617 Lineage on the Human ACE2 Receptor Binding: A Structural Insight.

Viruses - 17 Nov 2021

Khan Mohd Imran, Baig Mohammad Hassan, Mondal Tanmoy, Alorabi Mohammed, Sharma Tanuj, Dong Jae-June, Cho Jae Yong

Abstract excerpt

The recent emergence of novel SARS-CoV-2 variants has threatened the efforts to contain the COVID-19 pandemic. The emergence of these "variants of concern" has increased immune escape and has supplanted the ancestral strains. The novel variants harbored by the B.1.617 lineage (kappa and delta) carry mutations within the receptor-binding domain of spike (S) protein (L452R + E484Q and L452R + T478K), the region...

Topics

Angiotensin-Converting Enzyme 2
Antibodies, Monoclonal, Humanized
Antibodies, Neutralizing
Antibodies, Viral
Binding Sites
COVID-19
Humans
India
Molecular Dynamics Simulation
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

Protein Conformation

SARS-CoV-2

Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 34835101
DOI: 10.3390/v13112295
PMCID: PMC8625741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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