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Article

Impact of Somatic DNA Repair Mutations on the Clinical Outcomes of Bone Metastases from Castration-Resistant Prostate Cancer.

International journal of molecular sciences - 4 Aug 2023

Cursano Maria Concetta, Giunta Emilio Francesco, Scarpi Emanuela, Casadei Chiara, Virga Alessandra, Ulivi Paola, Bleve Sara, Brighi Nicole, Ravaglia Giorgia, Pantano Francesco, Conteduca Vincenza, Santini Daniele, De Giorgi Ugo

Abstract excerpt

Up to 80% of castration-resistant prostate cancer (CRPC) patients develop bone metastases during the natural history of disease and about 25% harbor mutations in DNA damage repair (DDR) genes. This retrospective observational study evaluated the prevalence of DDR alterations in CRPC patients and their effect on the clinical outcomes associated with bone metastases. The mutational status of CRPC patients was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37569810
DOI: 10.3390/ijms241512436
PMCID: PMC10419855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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