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Foot-and-mouth disease virus induces PERK mediated autophagy to suppress antiviral interferon response

1 Jan 2020

Abstract excerpt

Foot-and-mouth disease virus (FMDV) is a picornavirus that causes contagious acute infection in cloven-hoofed animals. FMDV replication-associated viral protein expression induces endoplasmic reticulum (ER) stress and the unfolded protein response (UPR), in turn inducing autophagy to restore cellular homeostasis. We observed that inhibition of BiP (also known as HSPA5 and GRP78), a master regulator of ER stress...

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PMID: 32482793
DOI: 10.1242/jcs.240622

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