Article
A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis.
Cell reports - 19 Oct 2021
Nakagawa Toshinori, Jörg David J, Watanabe Hitomi, Mizuno Seiya, Han Seungmin, Ikeda Tatsuro, Omatsu Yoshiki, Nishimura Keiko, Fujita Miyako, Takahashi Satoru, Kondoh Gen, Simons Benjamin D, Yoshida Shosei, Nagasawa Takashi
Abstract excerpt
In mouse testis, a heterogeneous population of undifferentiated spermatogonia (Aundiff) harbors spermatogenic stem cell (SSC) potential. Although GFRα1+ Aundiff maintains the self-renewing pool in homeostasis, the functional basis of heterogeneity and the implications for their dynamics remain unresolved. Here, through quantitative lineage tracing of SSC subpopulations, we show that an ensemble of heterogeneous...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.