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Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples

8 Jan 2021

Abstract excerpt

SARS-CoV-2 induces a muted innate immune response compared to other respiratory viruses. Mitochondrial dynamics might partially mediate this effect of SARS-CoV-2 on innate immunity. Polypeptides encoded by open reading frames of SARS-CoV and SARS-CoV-2 have been shown to localize to mitochondria and disrupt Mitochondrial Antiviral Signaling (MAVS) protein signaling. Therefore, we hypothesized that SARS-CoV-2...

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PMID: 33420163
DOI: 10.1038/s41598-020-79552-z

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