Article
Screening of high-risk deleterious missense variations in the CYP1B1 gene implicated in the pathogenesis of primary congenital glaucoma: A comprehensive in silico approach.
PeerJ - 1 Jan 2022
Shahid Muhammad, Azfaralariff Ahmad, Tufail Muhammad, Hussain Khan Nazeer, Abdulkareem Najm Ahmed, Firasat Sabika, Zubair Muhammad, Fazry Shazrul, Law Douglas
Abstract excerpt
Background: Primary congenital glaucoma (PCG) is the most common subtype of glaucoma caused by defects in the cytochrome P450 1B1 (CYP1B1) gene. It is developing among infants in more than 80% of cases who exhibit impairments in the anterior chamber angle and the trabecular meshwork. Thus, a comprehensive in silico approach was performed to evaluate the effect of high-risk deleterious missense variations in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.