Article
Genome-wide analysis of a model-derived binge eating disorder phenotype identifies risk loci and implicates iron metabolism.
Nature genetics - 1 Sept 2023
Burstein David, Griffen Trevor C, Therrien Karen, Bendl Jaroslav, Venkatesh Sanan, Dong Pengfei, Modabbernia Amirhossein, Zeng Biao, Mathur Deepika, Hoffman Gabriel, Sysko Robyn, Hildebrandt Tom, Voloudakis Georgios, Roussos Panos
Abstract excerpt
Binge eating disorder (BED) is the most common eating disorder, yet its genetic architecture remains largely unknown. Studying BED is challenging because it is often comorbid with obesity, a common and highly polygenic trait, and it is underdiagnosed in biobank data sets. To address this limitation, we apply a supervised machine-learning approach (using 822 cases of individuals diagnosed with BED) to estimate the...
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