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Arsenic affects homologous recombination and single‐strand annealing but not end‐joining pathways during DNA double‐strand break repair

2 Aug 2023

Abstract excerpt

Arsenic is a carcinogen that can cause skin, lung, and bladder cancer. While DNA double‐strand breaks (DSBs) have been implicated in arsenic‐induced carcinogenesis, the exact mechanism remains unclear. In this study, we performed genetic analysis to examine the impact of arsenic trioxide (As2O3) on four different DSB repair pathways using the human pre‐B cell line Nalm‐6. Random integration analysis showed that...

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PMID: 37530740
DOI: 10.1111/febs.16922

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