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Article

Arsenic inhibition of telomerase transcription leads to genetic instability

15 Nov 2001

Abstract excerpt

Arsenic is effective in the treatment of acute promyelocytic leukemia. Paradoxically, it is also carcinogenic. In the process of elucidating a mechanism of arsenic resistance in a leukemia cell line, NB4, we discovered that arsenic exposure causes chromosomal abnormalities, with a preponderance of end-to-end fusions. These chromosomal end fusions suggested that telomerase activity may be inhibited by arsenic. We...

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Share to Retinoids in leukemia and cellular processes
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PMID: 11714746
DOI: 10.1172/jci14064

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