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Article

Performance of clinical risk scores and prediction models to identify pathogenic germline variants in patients with advanced prostate cancer.

World journal of urology - 1 Aug 2023

Rebhan Katharina, Stelzer Philipp D, Pradere Benjamin, Rajwa Pawel, Kramer Gero, Hofmann Bernd, Resch Irene, Yurdakul Ozan, Laccone Franco A, Bujalkova Maria Gerykova, Smogavec Mateja, Tan Yen Y, Ristl Robin, Shariat Shahrokh F, Egger Gerda, Hassler Melanie R

Abstract excerpt

PURPOSE: Determining the frequency and distribution of pathogenic germline variants (PGVs) in Austrian prostate cancer (PCa) patients and to assess the accuracy of different clinical risk scores to correctly predict PGVs. METHODS: This cross-sectional study included 313 men with advanced PCa. A comprehensive personal and family history was obtained based on predefined questionnaires. Germline DNA sequencing was...

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PMID: 37528288
DOI: 10.1007/s00345-023-04535-4
PMCID: PMC10415416

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