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Article

Rational design of a booster vaccine against COVID-19 based on antigenic distance

31 Jul 2023

Abstract excerpt

Current COVID-19 vaccines are highly effective against symptomatic disease, but repeated booster doses using vaccines based on the ancestral strain offer limited additional protection against SARS-CoV-2 variants of concern (VOCs). To address this, we used antigenic distance to in silico select optimized booster vaccine seed strains effective against both current and future VOCs. Our model suggests that a...

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PMID: 37527659
DOI: 10.1016/j.chom.2023.07.004

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