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Article

Intersecting SARS-CoV-2 spike mutations and global vaccine efficacy against COVID-19.

Frontiers in immunology - 1 Jan 2025

Tokhanbigli Samaneh, Salami Ghaleh Samira, Rahimian Karim, Mahmanzar Mohammadamin, Bayat Saleha, Ahangarzadeh Shahrzad, Moradi Bahman, Mahmanzar Reza, Wang Yunliang, Oliver Brian Gregory George, Deng Youping

Abstract excerpt

In line with encountering the world with the emergence of vaccine-resistance variants of SARS-CoV-2, 15,669,529 samples that received COVID-19 vaccines until April 2023 were investigated as two doses in the first phase and booster vaccinations in the second phase. The analysis shows that D614G and P681 mutations occurred in both phases. The E484 and Y655 mutations significantly emerged during the second phase....

Read the complete abstract on PubMed

Topics

SARS-CoV-2
Humans
COVID-19
COVID-19 Vaccines
Spike Glycoprotein, Coronavirus
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Vaccine Efficacy

Source

Open in PubMed Open full text

Identifiers

PMID: 40124365
DOI: 10.3389/fimmu.2025.1435873
PMCID: PMC11925781

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