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ShinyBioHEAT: an interactive shiny app to identify phenotype driver genes in E.coli and B.subtilis.

Bioinformatics (Oxford, England) - 1 Aug 2023

Wang Chen, Govindarajan Harikumar, Katsonis Panagiotis, Lichtarge Olivier

Abstract excerpt

SUMMARY: In any population under selective pressure, a central challenge is to distinguish the genes that drive adaptation from others which, subject to population variation, harbor many neutral mutations de novo. We recently showed that such genes could be identified by supplementing information on mutational frequency with an evolutionary analysis of the likely functional impact of coding variants. This...

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PMID: 37522889
DOI: 10.1093/bioinformatics/btad467
PMCID: PMC10412404

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