Article
The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis.
International journal of molecular sciences - 19 Jul 2023
Kiełbowski Kajetan, Herian Mariola, Bakinowska Estera, Banach Bolesław, Sroczyński Tomasz, Pawlik Andrzej
Abstract excerpt
Osteoarthritis (OA) is progressive disease characterised by cartilage degradation, subchondral bone remodelling and inflammation of the synovium. The disease is associated with obesity, mechanical load and age. However, multiple pro-inflammatory immune mediators regulate the expression of metalloproteinases, which take part in cartilage degradation. Furthermore, genetic factors also contribute to OA...
Topics
- Osteoarthritis
- Epigenomics
- Humans
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Inflammation
- Animals