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Topological deep learning based deep mutational scanning.

Computers in biology and medicine - 1 Sept 2023

Chen Jiahui, Woldring Daniel R, Huang Faqing, Huang Xuefei, Wei Guo-Wei

Abstract excerpt

High-throughput deep mutational scanning (DMS) experiments have significantly impacted protein engineering, drug discovery, immunology, cancer biology, and evolutionary biology by enabling the systematic understanding of protein functions. However, the mutational space associated with proteins is astronomically large, making it overwhelming for current experimental capabilities. Therefore, alternative methods for...

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PMID: 37506452
DOI: 10.1016/j.compbiomed.2023.107258
PMCID: PMC10528359

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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